The research provides some insight into why long-term exposure to NSAIDs might be deleterious to the elderly: signaling by the prostaglandin PGE2 is required for the function of muscle stem cells, and inhibiting PGE2 signaling with NSAIDs or genetic knockout accelerates the decline in muscle strength with age. Conversely, PGE2 treatment increases the survival of aged muscle stem cells in vitro.
Even more exciting, intramuscular injection of PGE2 restores the regenerative capacity of aged muscle stem cells in vivo, increasing their capacity to regenerate in response to injury. Together, these findings indicate that PGE2 is an essential mediator of muscle stem cell regeneration.
Pioneer: Adelaida Palla (Blau lab/Stanford)
Review: Chris Patil (Hourglass)