Abstract: Are reactive oxygen species (ROS) good or bad? It depends on the context. On the good side, these compounds regulate cellular signaling and physiological responses, but on the bad side, they can promote oxidative damage. To reconcile these somewhat contradictory findings, researchers have proposed that low levels of ROS are favorable, whereas high levels are deleterious.
Sounds reasonable, right? Unfortunately, right now there’s no clear definition of “low” and “high,” enabling anyone to fit their story into that very broad picture. To refine the model, Wong proposes that we should think about the proximity of ROS generation to various cellular components. After all, an oxidative molecule that is generated next to an oxidation sensor will have a very different effect than one generated next to a highly susceptible, physiologically important molecule. Moreover, it is necessary to define the relative contributions of different sources of ROS.
Pioneer: Helen Wong (Brand Lab/Buck)
Agent: Chris Patel (Hourglass)